426 Thompson, Ann Arbor, MI United States,
Speaker: Dr. Elissa Chesler
Title: Improving the classification of psychiatric disorders through genetics and genomics
Classification, research and treatment of psychiatric disorders is challenged by their tremendous heterogeneity. Advances in functional genomics provide an opportunity to refine the classification of behavior based on intrinsic biological mechanisms. Computational advances, data aggregation techniques and functional genomics strategies including our GeneWeaver web-based software system enable us to address the challenge of distinguishing among many interrelated disorders, and developing research resources for the further characterization of the biology of behavior.
1: Chesler EJ, Logan RW. Opportunities for bioinformatics in the classification of behavior and psychiatric disorders. Int Rev Neurobiol. 2012;104:183211. doi: 10.1016/B9780123983237.000082. PubMed PMID: 23195316.
2: Chesler EJ. Out of the bottleneck: The Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research. Mamm Genome. 2014 Feb;25(12):311. doi: 10.1007/s0033501394929. Epub 2013 Nov 23. Review. PubMed PMID: 24272351; PubMed Central PMCID: PMC3916706.
3: Bubier JA, Chesler EJ. Accelerating discovery for complex neurological and behavioral disorders through systems genetics and integrative genomics in the laboratory mouse. Neurotherapeutics. 2012 Apr;9(2):33848. doi: 10.1007/s1331101201113. Review. PubMed PMID: 22422471; PubMed Central PMCID: PMC3325414.
4: Baker EJ, Jay JJ, Bubier JA, Langston MA, Chesler EJ. GeneWeaver: a web-based system for integrative functional genomics. Nucleic Acids Res. 2012 Jan;40(Database issue):D106776. doi: 10.1093/nar/gkr968. Epub 2011 Nov 12. PubMed PMID: 22080549; PubMed Central PMCID: PMC3245070.