January 1, 2016 – Network heterogeneity and seizure generation
It has been shown that seizures occur more frequently at the transition from wake to sleep, or from one stage of sleep to another. Acetylcholine (ACh) is a neuromodulator that controls wake and sleep stages, and is present at high levels during waking and is absent in slow wave sleep (SWS). ACh has also been shown to switch the excitability as measured with Phase response curves (PRC) of pyramidal cells from Type 2 to Type 1. In general, Type 1 neurons are integrating type with highexcitability while Type 2 have lower excitability but higher capacity for synchronization. We investigate the effect of non-uniform cholinergic modulation, such as might occur at sleep/wake transitions, on the propensity for neuronal synchronization in large-scale networks of Hodgkin-Huxley models for cortical pyramidal cells.